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MeissonnierGPintonPLaffitteJCossalterAMGongYYWildCet al
Computational models of complex Ca 2+ dynamics incorporating store-operated Ca 2+ entry and MAM geometry further underscore the nonlinear behavior of this system and its sensitivity to small changes in channel density, ER store content, or mitochondrial buffering capacity ( 2+ transfer and mitochondrial Ca 2+ overload are early pathogenic events, whereas oxidative stress, inflammatory activation, and impaired clearance of damaged mitochondria contribute mainly to propagation and amplification of acinar cell injury
Ethics declarations Competing interests C.J.H.P., N.L.T
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