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GLP-1 modulates actin polymerization, improving insulin sensitivity and glucose-stimulated insulin secretion Chronic hyperglycemia, or glucotoxicity, causes pancreatic cell dysfunction, diminished glucose-stimulated insulin secretion, and the production of long actin stress fibers 6,7

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EJNMMI Res 12:20 Koirala P, Chen SPR, Boer JC, Khalil ZG, Deceneux C, Goodchild G, Lu L, Faruck MO, Shalash AO et al (2023) Polymeric nanoparticles as a self-adjuvanting peptide vaccine delivery system: the role of shape