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Because MOTS-c is naturally produced in response to exercise, and because it activates the same AMPK and mitochondrial biogenesis pathways that exercise training upregulates, combining exogenous MOTS-c with a structured exercise program creates a reinforcing signal that operates through the same biological channels

doi: 10.1002/art.20850 125 DairaghiDJZhangPWangYSeitzLCJohnsonDAMiaoSet al

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