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That was the case for diaTribe CEO Jim Carroll, who microdoses tirzepatide (Mounjaro) to maintain the blood sugar benefits and protective effects for the heart and kidneys

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Only when insulin was given back to where it was missing, the portal vein, did serum IGF-1 levels normalize

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These effects were noted in obese mice and beta(3)-adrenergic receptor knock-out mice, suggesting that AOD-9604s actions are not mediated directly through the beta(3)-adrenergic receptor, a known facilitator of lipolysis