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J Clin Endocrinol Metab 83:8187 Wei S, Tanaka H, Kubo T, Ono T, Kanzaki S, Seino Y (1997) Growth hormone increases serum 1,25-dihydroxyvitamin D levels and decreases 24,25-dihydroxyvitamin D levels in children with growth hormone deficiency

Children: Preschoolers (3-5 years) should get 10 to 13 hours, while school-age kids (6-13 years) should strive for nine to 11 hours each night

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Reactions that spread beyond the immediate injection area, involve significant swelling, or are accompanied by fever or systemic symptoms require medical evaluation

This leads to a decrease in vascular resistance and an increase in plasma volume