[18] [19] Side effects [edit] The most common side effects include gastrointestinal disorders, such as dyspepsia, decreased appetite, nausea, vomiting, abdominal pain, diarrhea
Contrave (Naltrexone/Bupropion) Contrave is a combination medication containing two active ingredients: naltrexone (an opioid blocker) and bupropion (which affects dopamine and norepinephrine)
Each of these drugs is also marketed under a different name for the treatment of diabetes: semaglutide (Ozempic), tirzepatide (Mounjaro), and liraglutide (Victoza)
The FDA has received reports of acute pancreatitis in patients using semaglutide and tirzepatide, though causality remains uncertain and incidence rates remain low
The 10 mg dose of tirzepatide showed greater weight reduction versus semaglutide 1 mg by -1.8 mmHg (-3.4 to -0.1) while the 15 mg dose of tirzepatide reduced an additional -3 mmHg (-4.6 to -1.3) compared to semaglutide [65]
Compounded semaglutide products are not FDA approved, and the FDA has issued safety concerns regarding their use and variability in purity, potency, and ingredients
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