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GLP-1R expression on cells is low

The TCA cycle is the central metabolic hub of the cell

These promising results led to the development of the first dual agonists, with tirzepatide, a GIP and GLP-1 receptor agonist, being the most prominent one

Because semaglutide affects blood sugar and appetite, it must be used with caution, especially in individuals with certain health conditions or those taking other medications

Rapid introduction of GLP-1 receptor agonists at standard doses can provoke nausea, GI distress, and fatigue that go beyond typical side effects

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