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Louis Aronne is a paid consultant and advisory board member for Eli Lilly and Company, the study sponsor and the manufacturer of orforglipron and tirzepatide.
The Bottom Line Most GLP-1 side effects are temporary and manageable with small, consistent habits gentle meals, steady hydration, and provider-guided dosing
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Per a study published in April in Genome Medicine , people who carried certain mutations in their PAM (peptidyl-gylcine alpha-amidating monooxygenase) genes, which are key for processing hormones, were less likely to respond to GLP-1 drugs
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