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To unpack why the mechanism matters for dosing: NNMT sits at a metabolic crossroads

The Kraus 2014 Nature paper established that NNMT is highly expressed in adipose tissue (especially in obesity) and that NNMT knockdown in adipose protects against diet-induced obesity in mice

This is one of the most popular protocols in our clinic

Other forms of vitamin B12, like Adenosylcobalamin and Hydroxy B12 complex, also have a better bioavailability profile and boost energy levels better than cyanocobalamin

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Any weight change reflects actual tissue loss, which is slower but more meaningful