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A detail in the 2007 data deserves emphasis because it is routinely lost in translation: the active concentrations were extraordinarily low, on the order of 10 to 10 molar picomolar to nanomolar

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Indeed, modulating this axis can markedly alleviate drug- or toxin-induced hepatotoxicity (40,41,47), reverse the progression of liver fibrosis (61,64), effectively eliminate HCC cells (78,79), or counteract drug resistance in HCC cells (81), exhibiting a broad range of beneficial effects

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