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Similarly, ROS also enhance inflammation through NF-B pathway activation, leading to IB degradation, NF-B nuclear translocation, and transcriptional upregulation of inflammatory mediators [93, 94]

54 IllesS

Psychiatry 95, 9921005

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However, many studies have demonstrated that even in WT p53, the P72R SNP exerts an effect on its transcriptional regulation of target genes and subsequent activation of biological programs [16, 17, 22,23,24,25]