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The Nrf2 pathway is a key player in the antioxidant response to ROS accumulation that regulates glutathione peroxidase (GSH), heme oxygenase-1, NADPH oxidase (NOX) and several other critical pathways [80]

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*Correspondence: Qiuxin Chen, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Researchers interview both the patient and a family member or caregiver, then rate six key areas: memory, knowing where they are in time and place, judgment and problem-solving, etc., and these ratings are added up to arrive at a score between 0 and 18

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