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Selective and membrane-permeable small-molecule inhibitors of NNMT reverse high-fat-diet-induced obesity in mice and remodel adipocyte metabolism (open-access)

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All of the drugmakers face the prospect of more local competition in China, where Novo's patent on Wegovy's active ingredient semaglutide expires in 2026 and companies like CSPC Pharmaceutical Group and Hangzhou Jiuyuan Genetic Biopharmaceutical Co are developing their own versions of the drug

Results vary based on individual factors like adherence, metabolism, and lifestyle