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Since IGF-1 is also related to energy metabolism and body weight 32 , our current findings are consistent with former observations concerning BMI and adipokines as well as the findings on retinol binding protein (RBP)4 and the prognosis of ALS 3,19,33

Its amino acid sequence Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val is stable in stomach acid and stays active across many tissue types in animal models

daily) Presence of GI symptoms (nausea, vomiting, abdominal pain, constipation)

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These gastrointestinal issues can make long-term use challenging

PMID 23369637