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The trial product estimand assumed participants adhere to their assigned treatment during the trial

Response: We appreciate the comments on the C-APC methodology

Proc Natl Acad Sci (2008) 105(35):131638

"We want to try and get different predictors whether it's blood tests or psychological tests which can help us understand how a patient is likely to fare with each of these drugs," says Miras

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Results were weighted by market share, panel source mix, and evaluated channel to support comparability across firms