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From a safety perspective, SC administration of apomorphine may cause injection site reactions such as bruising (16%), granulomas (4%) or itching (2%), but these typically do not lead to discontinuation ( 5% of patients) [9]

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Study participants either were obese or were overweight with a weight-related condition (like hypertension) (3)

JAMA 298:11801188 Lago RM, Singh PP, Nesto RW (2007) Congestive heart failure and cardiovascular death in patients with prediabetes and type 2 diabetes given thiazolidinediones: a meta-analysis of randomised clinical trials

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Le Maire et al., 1986