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In fact, nearly all characteristic alterations associated with ovarian aging, including metabolic disturbances, oxidative stress, impaired steroidogenesis, and dysregulation of the immune microenvironment, reflect coordinated dysfunction across multiple organelles rather than isolated deterioration of a single organelle [20]

Cheng H, Ma K, Zhang L, Li G

As a key energy substrate for tumor cells, Gln can be catabolized by glutaminase to generate -ketoglutarate (-KG), which directly enters the tricarboxylic acid (TCA) cycle [1]

To enable clinical translation, issues such as biocompatibility, targeting accuracy, clinical safety, and human trials must be addressed

Biochim Biophys Acta (BBA) Rev Cancer

doi: 10.1007/s12020-017-1440-0 [PubMed: 29030774] [CrossRef] 76