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Grimsrud PA, Picklo MJ, Griffin TJ, Bernlohr DA

Liraglutide and semaglutide are long-acting human GLP-1 analogues with high receptor affinity and sustained receptor occupancy, whereas dulaglutide is a larger fusion molecule conjugated to an IgG4 Fc fragment, resulting in distinct pharmacokinetics and tissue distribution

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Contraindicated in cardiovascular disease, glaucoma, hyperthyroidism, pregnancy, breastfeeding, and children under 16

Participants experienced blood pressure drops, though the effect was more significant in those without diabetes and who took the medication for 50 to 100 weeks