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The SmPC specifically warns that dose reduction of these medications should be considered when initiating tirzepatide to reduce hypoglycaemia risk

Retatrutide, semaglutide, and tirzepatide occupy distinct positions on the receptor agonism spectrum

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People with CKD or other conditions affecting protein metabolism should seek specialist dietary advice before increasing protein intake

Furthermore, the numbers and distribution of pre-existing OGLDs in the T2D population were comparable and they were on a stable dose for at least 3 months

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