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These findings all indicate that ferroptosis promotes the development of DCM through abnormal iron metabolism, lipid peroxidation, ROS production, and enhanced cardiomyocyte inflammation (Figure 1)

Phenylephrine and pseudoephedrine decongestants may elevate blood pressure or heart rate, effects that overlap with semaglutide's cardiovascular monitoring needs

Gentile S, Strollo F, Guarino G

The findings were "striking," Al-Aly wrote in his Conversation piece

Key data from these trials are summarized inse drugs have not been rigorously evaluated in CKD and T2D and so are not indicated for use in CKD in the United States

They introduce additional CQAs that must be carefully monitored, including the proportion of conjugated versus unconjugated peptide, the presence of free form of the conjugate moiety (e.g., lipids, PEG chains), and the occurrence of di- or poly-PEGylation