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The increase in ROS or RNS levels involves a concomitant increase of proinflammatory cytokines and the activation of NF-, which in turn activates the hepatic stellate cells, the subsequent fibrosis, and damage to the DNA [12,64], with a failure in the synthesis of exogenous antioxidants [12]

[DOI] [PubMed] [Google Scholar] 157.Darweesh S.K., Ibrahim M.F., El-Tahawy M.A

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These suggests that the neuroprotective effects of berberine may be related to an excitatory mechanism that promotes cell survival and antioxidant-related signaling pathways

[DOI] [PMC free article] [PubMed] [Google Scholar] 103.Yang J., Ruchti E., Petit J., Jourdain P., Grenningloh G., Allaman I., Magistretti P.J