GFR 30-49 ml/min: 250-750 mg q12hr
This makes B12 injections an optimal choice for those with serious deficiencies and sensitive stomachs
True deficiency may be overlooked if folic acid is taken alone
(2013) characterized the role of NNMT in cancer cell metabolism, demonstrating that NNMT activity creates a metabolic sink for SAM
Intrinsic factor binds to vitamin B12, so that you can absorb it into the blood
Indications and Usage for Cyanocobalamin Cyanocobalamin is indicated for vitamin B 12deficiencies due to malabsorption which may be associated with the following conditions: Addisonian (pernicious) anemia Gastrointestinal pathology, dysfunction, or surgery, including gluten enteropathy or sprue, small bowel bacteria overgrowth, total or partial gastrectomy Fish tapeworm infestation Malignancy of pancreas or bowel Folic acid deficiency It may be possible to treat the underlying disease by surgical correction of anatomic lesions leading to small bowel bacterial overgrowth, expulsion of fish tapeworm, discontinuation of drugs leading to vitamin malabsorption (see Drug Interactions), use of a gluten-free diet in nontropical sprue, or administration of antibiotics in tropical sprue
