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Hold: Keep the dose constant across all 4 weeks rather than titrating

Jimnez et al., 2008

Dose Titration Schedules and Escalation Protocols Systematic titration optimizes dosing while managing side effects and costs

Huang N, Cao B, Brietzke E, Park C, Cha D, Pan Z, et al

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3 Extracellular matrix stiffness The extracellular matrix (ECM) is a key component of the tumor microenvironment, providing structural support and acting as a reservoir of cues, including biophysical signals such as matrix stiffness and viscoelasticity