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In addition to the previously identified biomarker groups, our mouse model enabled us to identify a third category, termed GH Treatment-Specific Responsive Biomarkers

Efficacy-to-tolerability ratio is lower for female rats on GLP1R agonists As a first step to investigate biological mechanisms underlying sex differences in the response to GLP1R agonists, we administered a single dose of semaglutide or tirzepatide in male and female Wistar rats across a wide range of doses (0.0003 mg/kg up to 0.3 mg/kg

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Bernaerts, S., Boets, B., Bosmans, G., Steyaert, J

While this approach can be useful, it is not always recommended

thus, investigating the conformational relationship between different natural plant polysaccharides with similar efficacy holds great significance for a thorough examination of their biological activity