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Under normal conditions, Nrf2 is degraded through its interaction with Kelch-like ECH-associated protein 1 (Keap1), whereas under oxidative stress conditions, Keap1 is oxidized and Nrf2 is translocated to the nucleus, where it induces the expression of several genes 19

PCA, principal component analysis

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Notably, GHK-Cu levels in circulation are known to decline with age, a pattern that has fueled substantial research interest in the peptide's potential relevance to tissue aging and regenerative capacity over the lifespan

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