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In lab and skin model studies, GHK-Cu shifts how fibroblasts behave, and fibroblasts are the cells that produce much of the collagen and elastin that keep skin firm

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10.3389/fnagi.2020.614650 Front Aging Neurosci

A Nature Scientific Reports 2016 study showed GHK-Cu had no cytotoxicity to human keratinocytes at concentrations up to 5,800 M over 72 hours and did NOT induce inflammatory biomarkers (IL-1, IL-8, HSPA1A, FOSL1) unlike other copper compounds, concluding GHK-Cu has a low potential of inducing skin irritation