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Their individual mechanisms are reasonably well-characterized in preclinical literature, even though human trial data remain sparse for both

D50.1 is underused

It acts as a ceRNA or sponge for miR-1184, which interacts with the 3'UTR of the IGFBP-2 mRNA, inhibiting its expression and resulting in decreased cell migration, invasion and growth

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To investigate whether FBXO22 serves as a critical mediator of the biological functions of BPC157, we established FBXO22-knockdown HUVEC models via siRNA-mediated gene silencing

iScience 25 , 105141 (2022)