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No serious adverse events were documented in the controlled trials reviewed here

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In vivo , receptor-targeted SPIONs accumulate intracellularly, as confirmed by Prussian blue staining, and demarcate infiltrative margins unseen with conventional agents (137, 138)

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Ethics declarations Ethics approval and consent to participate The study protocol was conducted according to the guidelines contained within the Declaration of Helsinki and was approved by the ethics committees of Yokohama City University and Kyoto Prefectural University