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While both can address aspects of mental well-being, they operate through different biological pathways

10.1016/j.chembiol.2018.01.011 44 FangX.CaiZ.WangH.HanD.ChengQ.ZhangP.et al (2020)

It is a protective factor

IGF-1 binding to the cysteine-rich domain of the subunits leads to sequential phosphorylation of Y1135, Y113, and Y1136 residues of the subunit which alters the structure of the chain, thereby turning on tyrosine kinase activity (Favelyukis et al., 2001)

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