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The outcome of corresponding or similar mutations in humans is described, as well as the potential mechanisms underlying increased longevity and the therapeutic benefits and risks of medical disruption of the GH/IGF-1 axis in humans

The GutBrain Axis and Appetite Regulation The gastrointestinal tract communicates directly with the brain through a network known as the gutbrain axis

Firriolo FJ, Hupp WS

Evaluation of fat mass and lean mass using Echo-MRI and X-ray CT system Consistent with the significant increase in body weight, vehicle-treated MC4R KO mice showed a significant increase in fat and lean masses

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