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Semaglutide works by slowing stomach emptying and reducing hunger signals in the brain, which can sometimes create conditions that trigger heartburn in certain individuals

10.1186/1742-2094-9-245 155 SanoY.ShimizuF.AbeM.MaedaT.KashiwamuraY.OhtsukiS.et al

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In major clinical trials, such as the landmark STEP 1 trial published in the New England Journal of Medicine , a once-weekly injection of semaglutide 2.4 mg resulted in an average body weight reduction of roughly 14.9% over 68 weeks