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Physical activity amplifies retatrutide results by preserving muscle mass during weight loss (critical for maintaining metabolic rate), increasing the caloric deficit beyond what appetite suppression alone achieves, and improving insulin sensitivity, which supports the metabolic effects of the medication

We believe there should be a concerted field-wide effort to design studies that can answer gating questions for real-world GLP-1 deployment for addiction: what do clinicians need to know and see to increase confidence in using GLP-1s for patients with SUD or SUD risk

PMID 26014293

Naltrexone may help normalize the mismatch between calories burned and appetite, especially in individuals with damaged metabolism

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