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Medications like orforglipron (an oral, non-peptide GLP-1 agonist), survodutide (a dual glucagon/GLP-1 agonist), and CagriSema (combining cagrilintide with semaglutide) are advancing through clinical trials

How does Wegovy work

The SUSTAIN-6 Trial (Once-Weekly Semaglutide) The Trial to Evaluate Cardiovascular and Other Long-term Outcomes with Semaglutide in Subjects with Type 2 Diabetes (SUSTAIN-6) consisted of 3297 people living with T2DM, 83% with established cardiovascular disease, receiving once-weekly semaglutide (0.5 and 1.0 mg) or placebo

While some experts and researchers have concerns about the drugs long-term impact and safety, many argue the benefits outweigh the known risks.

Microdosing GLP-1 helps calm appetite spikes, stabilize insulin response, and make body recomposition feel a bit more achievable without the heavy side effects that come with full medical doses

What makes Ozempic a popular choice for medical weight loss among GLP-1 medications