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Methamphetamine behaves as both a weak substrate and competitive inhibitor of CYP2D6, while MDMA acts as a high affinity substrate and potent mechanism-based inhibitor (MBI) of the enzyme

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ROS regulate the activity and subcellular localization of various enzymes and transcription factors through the reversible oxidation of redox sensitive amino acid residues [164], thereby exerting a profound impact on diverse cellular metabolic processes

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