Apr 2010;130(4):953-961
Due to its strong affinity for copper ions, GHK-Cu is commonly utilized in in-vitro and biochemical studies exploring cellular remodeling, peptide-metal interactions, and regulatory mechanisms associated with tissue structure and cellular adaptation
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No data exists on developmental effects, and cell proliferating properties raise theoretical concerns
As the identified di-, hexa- and decadepsipeptides are not in line with the proposed biosynthetic assembly of three ready-made tetradepsipeptides 8,9 , these findings prompted us to ask whether the candidate depsipeptide esters are released from chemically unstable NRPS-bound PCP- S -ester or TE- O -ester intermediates of cereulide biosynthesis upon transesterification with ethanol, or are formed as artifacts by esterification of free depsipeptides or as cereulide degradation products released upon ethanolysis