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Since NAL is a non-specific antagonist, the regional effect of NAL could be determined by the relative involvement of different opioid receptors in regulating DA neurons and DA release

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60 To date, 684 patients have been treated in a clinical setting

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This is in contrast to most previous and ongoing clinical trials in which patients with NASH and significant or advanced fibrosis were included and largely failed to show improvement in fibrosis [5]