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Animals were then quickly sacrificed 1 min after completion of the infusion, and tissues rapidly excised, snap-frozen, and stored at 80 C for receptor activation assays

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doi: 10.3389/fgene.2023.1118391 374 LiuLLianNShiLHaoZChenK

Common justifications include allergy or sensitivity to an inactive ingredient in the commercial product, need for a specific dose not available commercially, or documented medical need for the additional niacinamide component