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In REDEFINE 1, GI events were reported in 79.6% of CagriSema participants versus 39.9% on placebo, including nausea (55%), constipation (30.7%), and vomiting (26.1%)

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Long-term efficacy of liposomal nanocarriers of preassembled glycocalyx in restoring cerebral endothelial glycocalyx in sepsis

Safety animal and some human data profiles generally look good, but clinical fertility trials are sparse

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