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Obesity represents an inflammatory state associated with chronic activation of the immune system due to accumulated fat and the endocrine role of the adipocyte producing adipocytokines

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Hydrogen-producing bacteria are associated with diarrhoea, while methane-producing microorganisms (now classified as intestinal methanogen overgrowth or IMO) are more closely linked to constipation

Chronic low-grade inflammation, however, can perpetuate tissue damage and prevent resolution

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