Even though oral treatments of the methyl donor SAM ameliorated ASD-associated deficits in valproic acid (VPA)-exposed mice by reversing epigenetic changes, there has been limited success thus far in the development of preventative agents similar to SAM for the clinical management of ASD in humans
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Caution should be applied to the interpretation of this retrospective study since only half of the patients were able to comply with the diet and the side effects reported suggest potential long-term tolerability and safety issues (kidney stones, increased cholesterol) (Strubl et al., 2021)
