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Functional enrichment (GO/KEGG) and Gene Set Enrichment Analysis (GSEA) revealed that GGCT knocking down significantly impacted pathways related to the cell cycle, oxidative stress, cell proliferation, and cell death in both cancers (Fig

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Chronic inflammation is associated with increased oxidative stress, which arises from the generation of ROS and advanced glycation end products (AGEs) (Ha et al., 2024)

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doi: 10.1371/journal.pone.0121971 30 NetzerNGattererHFaulhaberMBurtscherMPramsohlerSPestaD

Future work should focus on 3D cultures and in vivo animal models that more accurately mimic a natural cellular environment, allowing a true evaluation of the peptides effectiveness as an anti-aging compound