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Growth hormone levels (IGF-1) and inflammatory markers may also inform response

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Stratified analyses by ejection fraction revealed that patients with borderline LVEF (5055%) exhibited more pronounced cardiovascular benefits, highlighting potential therapeutic overlap between HFpEF and HFmrEF

Moreover, because the TMD is less accessible than the extracellular region, this approach may facilitate the design of peptide ligands with moderate binding to better distinguish between target cells and nontarget cells

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