If youre starting at the recommended 0.25 mg dose, its completely normal not to notice any dramatic changes
25 GossetPWallaertBTonnelABFourneauC
Convenient tests that measure total plasma antioxidant activity by a commercial kit, or so-called TRAP and FRAP assays that have been used in clinical trials (10, 80), are misleading in monitoring micronutrient therapy because they are largely influenced by those compounds : ascorbic acid contributes 20% to the FRAP reading, vitamin E 5%, -carotene very little and thiols none (30)
Several microbial metabolites have been linked to CVD (25) including bile acids, SCFAs, branched-chain amino acids, TMAO, tryptophan, and indole derivatives (42)
And yes, there can be a weight gain rebound if the entire weight loss strategy was based on the GLP-1 effect
Cortisone has more human clinical evidence