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GAD67 is encoded by the GAD1 gene and expressed in the neuronal soma or throughout the entire neuron, whereas GAD65 is encoded by the GAD2 gene and expressed at axon terminals

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Clinical trials demonstrated meaningful reductions in body weight and fat mass, with particular effectiveness for visceral adipose tissue

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This process thereby downregulates the NF-B pathway, augments Treg differentiation, and suppresses Th17 expansion and inflammatory cytokine release (215, 216)

Psychopharmacology (Berl) 160: 353-361