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Those who had taken and then stopped GLP-1s had an increased risk of preterm delivery, gestational diabetes, and hypertensive disorders of pregnancy , such as gestational high blood pressure and preeclampsia, the analysis found

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When semaglutide modulates hypothalamic activity, it may decrease both dopamine and norepinephrine in regions critical for sexual arousal and orgasm

Reductions in liver fat are typical, with one study demonstrating an 86% decrease after 48 weeks

Additionally, in order to exclude an irritation reaction that may cause false positivity, skin tests at increasing concentrations were applied to 4 patients who were using exenatide without any problem with the same indication and revealed no positivity (shown in Fig

At the research level, the molecule has also attracted attention for effects observed on hepatic fat content, cardiometabolic biomarkers, and glycemic control that go beyond simple body-composition changes