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(13) Preclinical studies have demonstrated that GLP-1 receptor agonists like exenatide can enhance bone mass in diabetic and insulin-resistant rat models by upregulating OPG expression and improving the OPG/RANKL ratio

Other studies have reported similar synergistic effects for high-dose VitC combined with EGFR inhibitors cetuximab and gefitinib in KRAS mutated colon cancer and NSCLC cells respectively [99, 109]

41 All analyses were performed using GraphPad Prism software (GraphPad Prism Version 10.3, San Diego, CA) and R studio (Version 2024.12.0 + 467)

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Mindful Eating Practice mindfulness techniques such as paying attention to your hunger and fullness cues, eating slowly and without distractions, and savoring the flavors and textures of your food

Important Safety Information Who should not use tirzepatide: Type 1 diabetes patients (tirzepatide is not approved for type 1 diabetes) History of medullary thyroid carcinoma (MTC) Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)