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It is a chronic, progressive disease, characterized by multiple defects in glucose metabolism, the core of which is insulin resistance, which is the impaired ability to respond to insulin especially in muscle, liver, and adipocytes, and by a gradual -cell failure [161,162]

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Convenient oral research format : Supplied as pre-measured 500 mcg capsules, this presentation supports consistent, repeatable dosing in research protocols

Circulation Research 134, 12921305