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PDK, pyruvate dehydrogenase kinase 4

This increases intragastric pressure and can promote reflux of stomach contents into the oesophagus, leading to heartburn and reflux symptoms

Taking these drugs with Vyvanse can cause Vyvanse to build up in your body

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These dysfunctions may arise from impaired pyruvate dehydrogenase (PDH) function identified in muscle cells (390) and serum (184), as well as reduced plasma coenzyme Q10 (CoQ10) levels in ME/CFS blood and plasma (372, 391) that is inversely associated with fatigue severity (391)

This leads to an increase in intracellular cyclic adenosine monophosphate ( cAMP ) levels