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While the original 2002 paper in the Journal of Cosmetic Dermatology is referenced throughout current dermatology literature (including Pickart & Margolina, 2018), direct access is available through Wiley Online Library
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A prior study demonstrated that NLRP3 inflammasome activation induced the generation of mtROS, which directed the binding of GSDMD to the mitochondrial membrane, thus forming mitochondrial GSDMD pores and then causing the release of mtROS (82)
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These additions strengthen mechanistic links between intestinal dysfunction and hepatic pathology
NAD + also plays an important role in DNA repair, serving as a substrate for poly-(ADP-ribose) polymerase (PARP) enzymes that are involved in the response to DNA damage (127130)
