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After anesthesia, an equal amount of PBS, RBITC-GLP-1RAs@NPs or RBITC-GLP-1RAs@NPs-WYRGRL was injected into each rat through the tail vein, and fluorescence imaging of the heart, liver, spleen, lungs, kidneys, and both lower limbs was performed on the first and third days using an in vivo imaging system
Standard IGF-1 requires multiple daily injections to maintain therapeutic levels, while IGF-1 LR3 can be administered once daily or every other day depending on protocol design
Mn-SOD gene expression is induced by various stimuli, including inflammatory cytokines, fluctuations in redox equilibrium, ionizing radiation, and even cigarette smoke
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